The Effect of Silodosin in Patients with Benign Prostatic Hyperplasia: A Clinical Study of 100 Cases in India

Benign Prostatic Hyperplasia (BPH) Is A Chronic Condition Often Associated With Lower Urinary Tract Symptoms (LUTS) (Urinary Frequency, Urgency, A Weak And Intermittent Stream, Needing To Strain, A Sense Of Incomplete Emptying And Nocturia[1]). The Severity Of BPH-Related Luts Appears To Depend, At Least in Part, On Smooth Muscle Tone in The Prostate And Bladder Neck, Which is Mediated By Α1aAdrenoceptors. Silodosin, A New Α1aAdr. Selective Antagonist, Has Been Reported To Be Effective For Both Storage And Voiding Symptoms in BPH Patients [2]. This Study Include Assessment Of The Efficacy Of Silodosin On American Urological Association Symptoms Score (AUA) [3], Quality Of Life (QoL) And Post Void Residual Urine And Side Effects Of Silodosin.. In This Study The Majority Of Patients Were Above 56 Years (85%).There Were 54.54% And 42.85% reductions in Obstructive & Irritative AUA-SS respectively(Total50%) with Significant Improvement In QoL (51.11%) And In Post Void Residual Urine. The Major Adverse Effects were Retrograde Ejaculation(20%) &Upper Respiratory Tract Infection (15%).We Concluded That Silodosin is Effective For Both Storage And Voiding Symptoms In BPH Patients with Less Cardiovascular Side Effects.